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The potential of GLP-1RAs to reduce alcohol consumption in humans was first reported at a scientific conference in 2011.141 An RCT157 evaluated the effect of 26 weeks of once-weekly exenatide treatment on the frequency of heavy drinking days in patients diagnosed with AUD

Substance use disorders (SUDs) continue to affect millions worldwide, challenging clinicians to find more effective and sustainable treatments

However, experts have warned the approach is dangerous, with some people taking unlicensed versions of semaglutide ending up needing emergency hospital care after buying from unregulated online sellers without a prescription

Tonneijck L, Muskiet MH, Blijdorp CJ, Smits MM, Twisk JW, Kramer MH, et al

The full clinical study protocol and prespecified statistical analysis plan are available in the Supplementary Information (Supplementary Notes 2 and 3)