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Suitability depends on BMI, health conditions, and long-term weight management goals

Mechanisms of obesity WAT releases the adipokine leptin, which regulates food intake, energy expenditure, and sympathetic innervation, while its deficiency impairs thermogenesis and lipolysis, contributing to poor fat metabolism and severe obesity (Wang et al

Monitoring both sides of this equation is important

The experiments were approved by the Dutch Central Animals Testing Committee (AVD1150020198686), considering mild discomfort for the food intake experiment and moderate discomfort for the photometry mice based on the surgery, individual housing and food restriction