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Phase I studies of the safety, tolerability, pharmacokinetics and pharmacodynamics of the dual glucagon receptor/glucagon-like peptide-1 receptor agonist BI 456906

The class of medications includes drugs sold under brand names like Ozempic, which were previously reserved for type 2 diabetes

The trial enrolled predominantly people with mild Alzheimers disease, measured by a test known as the Mini-Mental State Examination, a scale that goes up to 30

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Currently, there is no FDA-approved indication for GLP-1 receptor agonists or GIP/GLP-1 dual agonists specifically for lipedema treatment, and high-quality clinical trial evidence remains limited
