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This process involves AMPK activation in the hypothalamic ventromedial nucleus by GLP-1 or GLP-1RA, promoting brown adipose tissue thermogenesis and white adipose tissue browning

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Tirzepatide Tirzepatide is a dual agonist, targeting both GLP-1 and GIP (glucose-dependent insulinotropic polypeptide) receptors simultaneously

The drugs are also contraindicated in patients with a personal or family history of medullary thyroid carcinoma or in those with multiple endocrine neoplasia syndrome type 2
