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Patient safety advice should include: Reporting severe or persistent abdominal pain immediately Maintaining adequate hydration, particularly during gastrointestinal upset Monitoring for signs of depression or suicidal ideation (regulatory authorities are monitoring this signal, though no causal link has been established) Understanding that rapid weight loss may necessitate adjustment of other medications Regarding pregnancy , advice is product-specific: Wegovy and Saxenda are contraindicated in pregnancy

[28] A 2014 meta-analysis found no evidence for increased pancreatic cancer risk in people treated with DPP-4 inhibitors, but owing to the modest amount of data available, the authors were unable to completely exclude possibly increased risk

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