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evoke and evoke+: design of two large-scale, double-blind, placebocontrolled, phase 3 studies evaluating efficacy, safety, and tolerability of semaglutide in early-stage symptomatic Alzheimers disease

Oral semaglutide showed cardiovascular safety profile, with significant reduced risk of death from cardiovascular events

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Notably, these effects were not mimicked by E alone, which failed to rescue cycle perturbations and had a discernible uterotrophic action, but were replicated, in terms of reversal of irregularities of the ovarian cycle, by GLP1 alone, which nonetheless did not elevate LH levels

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