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This medication is meant to work in the SQ
Dilation and curettage (A) is typically offered to patients with heavy vaginal bleeding evidenced by hemodynamic instability

A 2 L injection volume was used

2017 Dec;87(6):767-774

[15] Estradiols hepatic effects include increased synthesis of clotting factors II, VII, IX, and X and decreased antithrombin III, changes that contribute to a small but significant rise in venous thromboembolism risk, particularly during the first treatment year and among carriers of factor V Leiden
