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Regarding non-fatal myocardial infarction, there was no statistically significant difference (RR 1.18
Drug Interaction Studies JANUMET XR Coadministration of multiple doses of sitagliptin (50 mg) and metformin HCl (1000 mg) given twice daily did not meaningfully alter the pharmacokinetics of either sitagliptin or metformin in patients with type 2 diabetes
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This highlights a burgeoning research interest in addressing genetic disorders that significantly impact metabolism
doi: 10.1080/14740338.2025.2499670.
