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After completion, as monitored by UPLC and ESI-LCMS, the reaction mixture was diluted with buffer A, filtered and purified directly by preparative RP-HPLC, eluting with a linear gradient (see the Peptide cleavage and purification section)

Mean MACE-related costs (for a first event) are estimated to be about $20,000 per patient

In vitro assessment of the effect of the modulators on the signaling profile of oxyntomodulin or GLP-1 936 amide indicates that their most prominent effect is to augment cAMP production, suggesting that this alone may be sufficient to improve insulin secretion, at least in the context of the baseline signaling of the peptides/modulators

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Glucagonlike peptide agonists: a prospective review