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These uses are off label, and NAD+ is not FDA-approved to diagnose, treat, cure, or prevent any disease

Engineering new ligands that specifically target multiple G protein-coupled receptors with desired activity profiles requires time-consuming and expensive cycles of design-make-test-analyse work

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Berberine is a plant alkaloid with modest metabolic effects, while Ozempic (semaglutide) is a prescription GLP-1 receptor agonist that produces sustained weight loss of 15-22% in clinical trials