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The European Medicines Agency, on April 12, 2024, concluded that there is no causal association between GLP-1 RAs and suicidal thoughts or actions [180]

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Circulation 148 , 16061635 (2023)

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These findings indicate that the protective effects of GLP-1RAs may involve shared molecular mechanismssuch as the AMPK/SIRT1 signaling pathwaywhile also exhibiting disease-specific regulation

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