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Because tirzepatide activates dual pathways, there has been speculation that it might preferentially protect muscle

We investigated the effects of a glucagon-like peptide-1 (GLP-1) receptor agonist on NAFLD, PLF and liver regeneration in mice fed chow diet or methionine/choline-deficient diet (MCD) or high fat diet (HFD)
HRT generally does not cause these symptoms unless oral delivery is irritating the stomach

Offering an alternative to pharma, however, is only one piece of the puzzle
doi:10.1038/nrendo.2010.187 118