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Ridker PM, Devalaraja M, Baeres FMM et al (2021) IL-6 inhibition with ziltivekimab in patients at high atherosclerotic risk (RESCUE): a double-blind, randomised, placebo-controlled, phase 2 trial

These findings indicate that incretin agonists have no direct actions in human hepatocytes or hepatic stellate cells, suggesting that their beneficial effects in patients with MASH are likely mediated indirectly, potentially through improvements in body weight, insulin resistance and glycemic control
The SELECT trial (2023) in non-diabetic patients with obesity and established CVD reported a 20% MACE reduction (HR 0.80, 95% CI 0.720.90), driven by reductions in MI and stroke, marking a paradigm shift for GLP-1 agonists in primary prevention [12]
Focus on your own numbers, your own health markers, and your own quality of life improvements

Generally, daily administration is recommended
