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Survodutides more measured profile may allow for: Better nutritional adherence More stable training performance Reduced risk of excessive lean tissue loss Importantly, there is no direct head-to-head data comparing muscle preservation between survodutide and retatrutide in trained athletes

2020;5(6) doi: 10.1172/jci.insight.133429

In clinical studies, retatrutide led to an average 2025% reduction in body weight over about one year

It also slows gastric emptying, meaning food remains in the stomach longer, which contributes to increased satiety and reduced calorie intake

GABAergic projections from lateral hypothalamus to paraventricular hypothalamic nucleus promote feeding