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In the past seven years, the proportion of new, commercial patients who are rejected for a launch brand increased from 37% to 56%, such that more than half of the attempts to initiate a new treatment in 2022 were unfilled the first year

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IR is associated with several groups of abnormal syndromes that include obesity, diabetes, metabolic dysfunction-associated fatty liver disease (MAFLD), cardiovascular disease, polycystic ovary syndrome (PCOS), and other abnormalities

Second, we complement the meta-analysis using a systematic literature review, focusing on distinct reward phases and applications in clinical populations that may account for variability across studies

When the overweight population is included, i.e