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More commonly used medications in the treatment of Type 2 DM include: Biguanide Dipeptidyl peptidase 4 (DPP-4) inhibitors Glucagon-like peptide 1 (GLP-1) receptor agonists Dual glucose-dependent insulinotropic polypeptide (GIP) and GLP-1 receptor agonists Sodium-glucose cotransporter 2 (SGLT2) inhibitors Sulfonylureas Thiazolidinediones (TZDs) Biguanide The first and most foundational medication in type 2 diabetes management is metformin , the only drug in the biguanide class

Together, these actions reduce hunger signals, blunt cravings, and improve blood sugar control so hunger driven by rapid glucose swings tends to fall away

For this reason, contraception is recommended during active GLP-1 therapy, and conception should be planned only after discontinuation and adequate washout time

2022 Mar 29;119(13):e2116506119

However, access to these drugs remains inconsistent across Canada, largely due to differences in coverage across public health plans, private insurance, and employer-sponsored group benefits