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59 Kastin and Akerstrom established in a landmark study that peripherally injected Exendin-4 passed readily through the BBB, facilitated by its lipophilicity, rather than becoming trapped in the endothelial cell

Their mechanisms include: Neurotransmitter release : They increase the release of dopamine and noradrenaline in the brain Reuptake inhibition : They block the reuptake of these neurotransmitters, prolonging their activity Cognitive enhancement : In ADHD, they improve attention, focus, and impulse control Appetite suppression : As a secondary effect, they typically reduce appetite through central mechanisms Cardiovascular stimulation : They increase heart rate and blood pressure through sympathetic nervous system activation Lisdexamfetamine is a prodrug that is converted to dexamfetamine in the body and provides a longer duration of action (typically up to 14 hours), while dexamfetamine is available in immediate-release tablets (lasting 3-5 hours)