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Klba G, Ayduran S, ener S, et al

Diarrhoea was among the most frequently reported adverse effects in the Phase 2 NEJM trial, occurring in a dose-dependent pattern and most commonly during dose escalation

All procedures were conducted at the National Institute on Drug Abuse (NIDA) Intramural Research Program and the Johns Hopkins Bayview Clinical Research Unit

However, severe vomiting, inability to maintain fluids, or signs of dehydration should be reviewed before continuing treatment

Obesity Society 2013 AHA/ACC/TOS guideline for the management of overweight and obesity in adults: a report of the American College of Cardiology/American heart association task force on practice guidelines and the obesity society