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Consistent with systemic exendin-4 dose-response studies, the dose of intra-VTA exendin-4 (0.05 g) used in these studies reduced cocaine seeking and did not affect ad libitum chow intake or promote malaise-like effects in rats [67, 110, 131]

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10.1056/NEJMoa1612917 41 HusainM.BirkenfeldA

The STAMPEDE trial showed that at five years, 29% of gastric bypass patients and 23% of sleeve gastrectomy patients achieved normal glucose levels without any diabetes medications
