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Non-Covalent albumin ligands in FDA-approved therapeutic peptides and proteins: Miniperspective
Up to 25% of people prescribed metformin, a biguanide and first-line oral agent for type 2 diabetes, report adverse GI effects, primarily diarrhoea and nausea

The interaction between these agents is not merely additive but appears to be complementary in ways that amplify individual benefits while potentially mitigating certain drawbacks

We require an initial in-person evaluation with lab work before prescribing GLP-1 medications

And it can be a major cause of low libido and many of the causes of low libido, like hormone imbalances and chronic health problems