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If you have type 2 diabetes or obesity and are already considering a GLP-1 agent for metabolic reasons, then the potential brain benefits are a compelling additional advantage

Result Of 73,636 global Individual Case Safety Reports (ICSRs) related to Semaglutide reported adverse reactions globally, 91 were associated with the adverse reaction NAION

And they say to themselves, I'm going to take a few more anyway, because they're used to it

Additionally, selective deletion of Gipr in brown adipose tissue significantly increases both fasting (overnight) and fed (1h re-feed) TG levels of high-fat fed mice ( Gipr BAT / mice fed a high-fat diet for 810 weeks housed at room temperature reveal significantly increased TG excursion, an effect lost upon 28 weeks of high-fat feeding (Kim et al., 2007a) mediated by resistin (Kim et al., 2007b) and in human adipocytes by increasing TORC2 and phospho-CREB nuclear localization to bind to the CRE-II promoter region (Kim et al., 2010)