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That extra force can push the needle deeper than intended, increasing the risk of muscle penetration

44 It was first used to treat type 2 diabetes (Ozempic , Novo Nordisk) as a subcutaneous injection given once weekly

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Beyond weight outcomes, the Phase 2 obesity trial also reported improvements in several cardiometabolic markers, including: Reductions in waist circumference Improvements in fasting glucose and insulin sensitivity Favourable changes in blood pressure and lipid profiles Phase 3 trials understood to form part of the TRIUMPH programme are now underway, evaluating retatrutide in broader populations including people with type 2 diabetes and cardiovascular disease