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Miguel ngel Rubio-Herrera reported receiving consulting fees and/or speaker from Amgen, Astra Zeneca, Boehringer-Ingelheim, Eli Lilly, Janssen, Merck, Mundipharma, Rubi, and Sanofi-Aventis

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Aging alters the vascular structure and function, such as intimal thickening, inflammation, and lipid deposition, thus accelerating the progression of atherosclerotic diseases [112]

2003;285:E90616

For the research community this means that clinical doses and durations are not validated , most of todays research protocols rely on animal models and hypothetical extrapolations
