tirzepatide type 1 diabetes Groundbreaking Trial Testing for Beyond glycemia: Comparing tirzepatide to

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The mean (standard deviation) age of the cohort was 56 (10.6) years, with a mean duration of diabetes of 7.4 (5.7) years, mean HbA1c of 8.2 (0.9)% [66.1 (10.1) mmol/mol], and mean body mass index (BMI) of 33.5 (6.8) kg/m 2

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The evidence now is reassuring: A 2025 meta-analysis in JAMA Psychiatry found no increase in depression or suicidality with GLP-1 medications versus placebo FDA and EMA reviews found no causal link between GLP-1s and suicidal behavior In fact, GLP-1-treated groups showed slightly lower rates of depressive symptoms in clinical trials (likely due to improved metabolic health and quality of life) Potential mental health benefits under investigation: Reduced binge-eating impulses Decreased cravings in substance use disorders Improved mood independent of weight loss (possibly via reduced inflammation and effects on brain reward circuits) Bottom line: With appropriate monitoring, psychiatrists can feel confident that adding a GLP-1 wont destabilize a patients mental state and may improve it

In a study in T2DM patients with a BMI 25-50 kg/m 2 retatrutide treatment significantly decreased body weight from baseline compared to placebo and dulaglutide and lowered the fasting lipid profile in a dose-dependent manner at 36 weeks (142)