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This meant that GLP-1RA could not only indirectly mediate M2 polarization of microglia by regulating Tregs, but also directly bind to GLP-1R on the membrane surface of microglia, completing M2 polarization through the GLP-1R/cAMP/PKA/IL-10 signaling pathway ( Recent research showed that GLP-1RA could reduce plasma TNF- levels induced by different Toll-like receptor agonists and significantly inhibit neuroinflammation ( Glp1r Tie2+/+ and Glp1r Tie2-/- mice, indicating that this activity was not dependent on the blood system or endothelial cells

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Electronic supplementary material (PDF 312 kb) Rights and permissions About this article Cite this article Hutch, C.R., Roelofs, K., Haller, A

Circulation, 145(8), 575585

This effect may occur independently or may indicate a hypersensitivity reaction