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Mechanism and Timing: Why Headaches May Occur with Semaglutide Headaches associated with semaglutide likely stem from multiple mechanisms: rapid changes in blood glucose levels during initial dosing, mild dehydration from gastrointestinal effects, or direct GLP-1 receptor signaling in pain-processing brain regions

GLP-1 and GLP-1/GIP are GLP1 receptor agonists originally developed for type 2 diabetes and now commonly used in medical weight management