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However, since the drugs were administered systemically in a simulated clinical manner, we cannot rule out the effect of GLP-1R in the peripheral system
[29] Pratt, E., Ma, X., Liu, R., Robins, D., Haupt, A., Coskun, T.,
7 The dose-response relation for fasting glycaemia (and HbA1C) has been confirmed in a large randomized double-blind study in 451 patients with type 2 diabetes
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Together, IUB288 provided a first opportunity to investigate chronic GcgR agonism with a pharmacokinetic profile not dissimilar to that of the GLP-1R mono-agonist Liraglutide
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