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Description
In trials of weekly GLP-1 receptor agonists (exenatide QW, albiglutide, or dulaglutide), mean changes in body weight were 0.7 to 1.6 kg for monotherapy and +0.3 to 3.1 kg in combination with oral antihyperglycemic therapies (1517)

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doi: 10.1080/00325481.2021.1971461

It comes down to how the drugs are designed: while semaglutide acts only on GLP-1 receptors, tirzepatide is a dual-target drug that also acts on GIP receptors (GIP, or gastric inhibitory polypeptide, is another hormone like GLP-1 that helps regulate insulin and blood sugar)

Irani also said if the medication isnt well regulated it can impact efficacy and have side effects