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Criteria for exclusion included weight loss greater than 10% of the group mean, reduced food or water intake, or lack of grooming behavior

and consider an induration of 5 mm a positive tuberculin skin test result, even for patients previously vaccinated with Bacille Calmette-Guerin (BCG)

The glucagon receptor component has been a particular focus of mechanistic investigation

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Lilly previously said that in one late-stage study, called TRANSCEND-T2D-1, retatrutide helped people with diabetes lower blood sugar and lose a significant amount of weight, which is notable since those who have diabetes tend to lose less weight on treatment than those who dont