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A 3-year extension of the SCALE trial showed that persons with overweight or obese and prediabetes taking liraglutide had a reduced risk for developing type 2 diabetes with greater weight loss compared to those taking a placebo [151] Arguably, the arrival of semaglutide more than five years later sparked the publics attention to GLP-1 agonist therapy

Based on existing registry data (e.g., FDA and EMA data), the patient should be informed that while there is no clear evidence of teratogenicity, intensified prenatal monitoring is required

But even someone with a lower BMI who experiences distress, fatigue, or social stigma from their weight deserves care

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Its important to note that GLP1 medications arent suitable for everyone