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Description

Its unique mechanism of action provides additional metabolic benefits, such as improved glucose control and appetite suppression, making it appealing for both weight loss and diabetes management

While data specific to GLP-1 RA discontinuation remain limited, a large-scale prospective study on weight cycling (mean age 63.6 years, at high risk of T2DM) reported that weight regain was typically characterized by an adverse shift in body composition, with FM returning to baseline levels while FFM declined by 1.50 kg (95% CI 0.662.35)

Further, to promote sustained weight management, GLP-1 RA users should be educated on healthy diets and physical activity recommendations, and support should be available to encourage long term behaviour change

One of the mechanisms by which these drugs work is by slowing the digestion of food by slowing gut motility as well as, in the case of the GLP-1/GIP co-agonists, reducing stomach acid