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Vogt LM, Elderman ME, Borghuis T, de Haan BJ, Faas MM, de Vos P

Therefore, we propose that the anti-inflammatory effect of GLP-1 is mediated through inhibition of AKT/NF-B and MAPK signaling pathways by affecting the expressions of TNF-, IL-6, and IL-1

A) Fluo-4-loaded HEK-GLP-1R cells were challenged with a range of concentrations of GLP-1 736 amide and fluorescence recorded as an index of [Ca2+]i

New evidence suggests semaglutide may provide direct liver protection in MASH through intrahepatic GLP-1 receptors, adding to the growing evidence of organ specific benefits seen in the heart and kidneys