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This extended activity is key to their therapeutic efficacy, enabling once-weekly dosing for many of these medications

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5:877-886 [PubMed: 28917545] 137

1 The Faculty of Sexual and Reproductive Healthcare (FSRH) confirms this position, contrasting it with tirzepatide, which does reduce oral contraceptive exposure and requires additional contraceptive precautions

Following PH, the reduction in liver mass leads to hormonal changes that shift glucose metabolism towards glycogenolysis and gluconeogenesis in the remnant liver 44 and promote glucose utilization towards the pentose phosphate cycle to provide NADPH for lipid and DNA synthesis 45