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Then, correcting deficiencies helps restore cellular function and improve mitochondrial energy production, support lean muscle mass, and create a more resilient metabolism that can better maintain weight and appetite regulation after coming off a GLP-1

The SELECT trial was the first large, randomized study to show that a drug used for obesity could reduce cardiovascular disease, says Isaacs

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Produces higher weight loss results than many alternatives Helps with appetite, blood sugar, and fat metabolism Compared to phentermine, tirzepatide is usually more effective but also more complex and long-term

In contrast, intermittent fasting works by limiting eating windows, which can reduce calorie intake but does not directly suppress hunger