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Approved in 2022 for diabetes (brand Mounjaro), tirzepatide produced extraordinary results in weight loss up to ~22% in obese participants at the highest dose in a phase 3 trial ( [137] )

For men, minimizing that tax is not optional, it is the difference between looking lean and looking depleted

[DOI] [PubMed] [Google Scholar] 99.McGuire D.K., Marx N., Mulvagh S.L., et al

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"At one year, weight loss is about 8%, but by three years, it's gone down to 6%," he says