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Topiramate is traditionally used for migraine prevention and in seizure prophylaxis

Rooney, K
doi: 10.2337/dc19-1892 [DOI] [PMC free article] [PubMed] [Google Scholar] 29.Usui R, Yabe D, Seino Y

Preclinical studies demonstrate that BefA increases -cell mass by promoting both neogenesis from endocrine progenitors and proliferation of mature -cells (Hill et al., 2022)

They're also hydrophilic, meaning they don't dissolve well in the fatty layers of skin