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As these drugs spread to younger and healthier people, a clinical guide tries to replace one-size-fits-all prescribing with something more honest about risk, goals, and how patients are treated.

GLP-1, a hormone secreted by the intestines, lowers blood glucose and promotes weight loss through multiple mechanisms: it enhances insulin secretion in a glucose concentration-dependent manner, suppresses glucagon release, delays gastric emptying, and reduces food intake via central appetite suppression

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