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These findings underscore the importance of distinguishing between metabolic therapies that actively modulate neuroprotective pathways, such as metformin, and those that primarily function through systemic appetite suppression

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A growing body of research has shown a close relationship between MDP and the above factors, and MDP improved the pathological response of cardiovascular disease (CVD) through a variety of mechanisms ( Recent studies have shown a protective effect of MOTS-c against cardiac dysfunction and pathological remodeling (33)