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According to Rubino, clinical trials are now being planned to assess whether higher doses of GLP-1 drugs can be used in the acute phase to help patients lose weight, followed by lower "maintenance" doses, which come with fewer side effects and can be prescribed on a long-term basis

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For most people, this effect helps support steady, comfortable eating patterns

While not a 1-to-1 substitution for anti-obesity drugs, fiber-rich foods work similarly and also keep you fuller for longer

A small increase in resting heart rate does not necessarily mean retatrutide causes serious heart problems, but heart safety is still being monitored because the medicine is investigational