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Description

After activating GLP-1R, Semaglutide promotes insulin secretion, inhibits gastric emptying and appetite, and at the same time enhances autophagy, inhibits oxidative stress and apoptosis

Long-acting glucagon-like peptide (GLP)-1 analogs are currently available in treating diabetes with widely established safety and extensively evaluated efficacy

However, it also turns out that interaction of GLP-1 agonists with receptors found on brain cells leads to feelings of satiety and reduced hunger

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