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The lower vestibular risk associated with tirzepatide may make it preferable for higher-risk patients, though this potential benefit must be weighed against other clinical considerations

Patients who have undergone cholecystectomy (gallbladder removal) can generally use weight loss injections safely, as there is no absolute contraindication to GLP-1 receptor agonist therapy in this population

Decisions should be based on the patients metabolic health, cardiovascular risk, weight history, medications, family history, and overall clinical picture