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GLP-1 analogs such as ROSE-010 have also shown therapeutic potential

In June 2025, MBX Biosciences announced that it has submitted an IND application to the FDA for MBX 4291, a long-acting GLP-1/GIP receptor co-agonist prodrug targeting obesity, which received regulatory clearance in July
The sampling universe is defined by the U.S
GLP-1 drugs contain peptide molecules that cannot pass the skin barrier through the current transdermal patch technology

Hasan M, Schwartz S, McKenna V, Ing R