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Description

Glossary AA arachidonic acid ACE angiotensin converting enzyme AcH acetylcholine AMP adenosine monophosphate Ang I/ II angiotensin I/ II APP aminopeptidase P APN aminopeptidase N AT1 angiotensin II receptor subtype 1 BA bile acid cAMP cyclic adenosine monophosphate CB1 cannabinoid type 1 CDCA Chenodeoxycholic acid CHF congestive heart failure COX cyclooxygenase CYP cytochrome P450 DASH dipeptidyl peptidase-IV activity and/or structure homologues DHETs dihydroxyepoxyeicosatrienoic acids DML designed multitarget ligand DPP4 dipeptidyl peptidase-4 EDR endothelium dependent relaxation EETs epoxyeicosatrienoic acids ENaCs epithelial sodium channels EPC epithelial progenitor cells FGS focal glomerulosclerosis FLINT Farnesoid X nuclear receptor ligand obeticholic acid for non-cirrhotic, non-alcoholic steatohepatitis FXR farnesoid X receptor GK Glucokinase GLP-1 glucagon-like peptide-1 GP(C)R G-protein coupled receptor HbA1c hemoglobin A1c hERG human ether-a-go-go-related gene HETE hydroxyeicosatrienoic acid HIF-1 Hypoxia-inducible factor 1-alpha HSCs human hepatic stellate cells IL-6 interleukin-6 HDL high-density lipoprotein HMG-CoA 3 hydroxy-3-methyl-glutaryl-coenzyme A LDL low-density lipoprotein LH lateral hypothalamus MCH melanin-concentrating hormone MCH-1R melanin concentrating hormone receptor 1 MCP-1 monocyte chemoattractant protein-1 MetS Metabolic syndrome NAFLD non-alcoholic fatty liver disease NASH non-alcoholic steatohepatitis NEP neutral endopeptidase OCA obeticholic acid OEA oleoylethanolamides PPARs proliferator-activated receptors PPCE post-proline cleaving enzyme RA(A)S renin-angiotensin-aldosterone system RXR retionoid-X-receptor SAR structureactivity relationship sDDP4 soluble dipeptidyl peptidase-4 sEH soluble epoxide hydrolase sEH-I soluble epoxide hydrolase-inhibitor SGLT-2 sodium-glucose cotransporter-2 SHR spontaneously hypertensive rats SHROB rat spontaneously hypertensive obese rat T2DM type 2 diabetes mellitus TGF- transforming growth factor beta TNF- tumor necrosis factor- TZD thiazolidinedione UUO unilateral ureteral obstruction VEGF vascular endothelial growth factor ZDF ratzucker diabetic fatty rat ZSF1 ratzucker fatty/spontaneously hypertensive heart failure F1 hybrid rat References 1 AlbertiK

Prior Authorization Insurance companies often require prior authorization for semaglutide, meaning your doctor must provide proof of medical necessity before they will cover the medication

Semaglutide has an elimination half-life of approximately one week and may remain in the circulation for up to 57 weeks after the final 25 mg tablet dose