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Reported EC50 values include: GIP receptor: Approximately 0.064 nM GLP-1 receptor: Approximately 0.775 nM Glucagon receptor: Approximately 5.79 nM In research models, retatrutide activates several metabolic pathways

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Keywords: Glucagon-like peptide-1 receptor agonists, GLP-1-RAs, Precision medicine, Cancer risk Introduction Amid the continuously increasing global incidence of diabetes, glucagon-like peptide-1 receptor agonists (GLP-1RAs) have emerged as a cornerstone in type 2 diabetes treatment, demonstrating remarkable efficacy in glycemic control and cardiovascular risk reduction [1, 2]

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