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At the currently approved maximum dose of 14mg, the PIONEER clinical trials showed weight loss of approximately 4-5kg (about 4-5% of body weight) over 26 weeks in patients with type 2 diabetes

The primary outcome was major adverse cardiovascular events (MACE)

Hair follicles, heart cells, and neurons all depend on minerals long before fat cells finish yielding stored energy

To confirm these results, expression of these cytokines was further assessed by enzyme-linked immunosorbent assay and real-time polymerase chain reaction and similar results were also observed

It was also one of the 10 drugs that were subject to Medicare price negotiations under the Inflation Reduction Act