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The areas of interest are the effects on glycemia, body weight, and cardiovascular risk markers
The first is through the manufacturer's discount programs: If uninsured or insurance doesn't cover Zepbound: Eli Lilly offers a capped cash price of $299$449 for Zepbound Kwikpens or vials, depending on dosage, on Ro and LillyDirect
Adding GIPR co-agonism (as in tirzepatide and retatrutide) introduces additional Gs signalling from a second receptor type expressed on adipocytes, beta cells, and hypothalamic neurones
Coaching helps participants augment medication use with sustainable lifestyle changes
