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View image online ( stylized scientific illustration of hormone receptors For patients with type 2 diabetes and established cardiovascular disease, incretin-based therapy that targets both the GLP-1 and GIP gut hormones is associated with significantly greater cardiorenal benefits than therapy that targets GLP-1 alone

Our view is beginning to lean toward the idea that the occurrence of SSIBs is more likely to be related to the mental state of the patient rather than GLP-1RAs

Monitor appropriately

Journal of diabetes research, 2018, 1205121

Those drugs are complex peptides that must be injected because they cannot survive the digestive system intact, and they cannot penetrate the skin in meaningful amounts either (6)