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These medications, which mimic the functions of the naturally occurring hormone GLP-1 (glucagon-like peptide-1), have been lauded for their efficacy in not only controlling blood sugar levels but also promoting weight loss

GLP-1 RAs also modulate the brains microenvironment by reducing neuroinflammation, allowing for more efficient neurogenesis

Whilst great advancements have been made over the last century with regard to understanding the regulation of metabolic homeostasis which has yielded new therapeutic options for diseases such as T2D, it is unlikely that highly desirable more efficacious treatments will be developed for metabolic disorders until the complex systemic regulation of metabolic homeostasis becomes more intricately understood

Real-world studies have shown heterogeneous findings