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For instance, GLP-1RAs can improve the levels of insulin, regulate the levels of sex hormone, improve the blood lipid profile, increase the levels of adiponectin, regulate autophagy, inhibit the production of liver glucose, reduce the liver fat content, as well as reduce the levels of plasma liver enzymes and liver steatosis

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Among these, compounds 53 (IC 50 = 4 nM) and 54 (IC 50 = 10 nM) exhibited high DPP-4 inhibitory activities, good efficacy, and selectivity in an oral glucose tolerance test in ICR mice (Figure 7)

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