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This twofold activation creates a synergistic effect: GLP-1 handles appetite suppression while GIP enhances insulin secretion and energy expenditure

Tips for managing nausea and vomiting Eat more slowly Eat smaller meals throughout the day Avoid greasy or high-fat foods Stay hydrated Avoid lying down after eating Try bland foods such as crackers or toast Ginger or peppermint may help relieve nausea If vomiting is severe, persistent, or preventing you from keeping fluids down, contact your healthcare provider

You should tell your provider about these affects so they can help you change your plan

et al., Semaglutide in Patients with Obesity-Related Heart Failure and Type 2 Diabetes, STEP-HFpEF DM, N Engl J Med 2024;390:1394-1407, DOI: 10.1056/NEJMoa2313917 21